Staffing cuts of this magnitude will have profound implications across HHS’s mission areas. While health equity focused programs had already been halted through prior directives, this action fully eliminates offices such as the Office of Infectious Diseases and HIV/AIDS Policy and the Office of Minority Health, which address structural and social drivers of health. Staffing for the Administration for Children and Families dropped nearly 40% within three months, which will effectively hinder or halt vital programs.